Intensive care medicine
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Intensive care medicine · Feb 2000
Randomized Controlled Trial Clinical TrialInhaled prostacyclin and platelet function after cardiac surgery and cardiopulmonary bypass.
To study the effects of 6 h inhalation of aerosolized prostacyclin (PGI2) on platelet function. ⋯ Inhalation of PGI2 for 6 h in patients after cardiac surgery is associated with impaired platelet aggregation detected by in vitro techniques, with no in vivo signs of platelet dysfunction.
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Intensive care medicine · Feb 2000
Comparative StudyAssessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution.
Transpulmonary double-indicator dilution is a useful monitoring technique for measurement of intrathoracic blood volume (ITBV) and extravascular lung water (EVLW). In this study, we compared a simpler approach using single arterial thermodilution derived measurements of ITBV and EVLW with the double-indicator dilution technique. ⋯ Determinations of ITBV and EVLW by single thermodilution agreed closely with the corresponding values from the double-indicator technique. Since transpulmonary single thermodilution is simple to apply, less invasive and cheaper, all these features make it a promising technique for the bedside. Nevertheless, further validation studies are needed in the future.
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Intensive care medicine · Feb 2000
Effect of inhaled nitric oxide in combination with almitrine on ventilation-perfusion distributions in experimental lung injury.
To investigate a possible additive effect of combined nitric oxide (NO) and almitrine bismesylate (ALM) on pulmonary ventilation-perfusion (V(A)/Q) ratio. ⋯ We conclude that NO + ALM results in an additive improvement of pulmonary gas exchange in an experimental model of ALI by diverting additional blood flow from non-ventilated lung regions towards those with normal V(A)/Q relationships.