Intensive care medicine
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Intensive care medicine · Apr 2000
Randomized Controlled Trial Clinical TrialDose-dependent effects of almitrine on hemodynamics and gas exchange in an animal model of acute lung injury.
To determine the dose-response relationship of almitrine (Alm) on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury (ALI). ⋯ In experimental ALI, effects of almitrine on oxygenation are dose-dependent. Almitrine is most effective when used at low doses known to mimic hypoxic pulmonary vasoconstriction.