Intensive care medicine
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Intensive care medicine · Nov 2002
Randomized Controlled Trial Comparative Study Clinical TrialAcute haemodynamic effects of a hypertonic saline/dextran solution in stable patients with severe sepsis.
To study the haemodynamic effects of a hypertonic saline/dextran solution compared with a normal saline solution in patients with severe sepsis. ⋯ Hypertonic saline/dextran solution may improve cardiovascular performance in severe sepsis without significant side effects. The haemodynamic effect appears related mainly to a volume effect.
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Intensive care medicine · Nov 2002
Randomized Controlled Trial Comparative Study Clinical TrialEffect of the humidification device on the work of breathing during noninvasive ventilation.
Heat and moisture exchangers (HME) increase circuitry deadspace compared to heated humidifiers (HH). This study compared the effect of HH and HME during noninvasive ventilation (NIV) on arterial blood gases and patient's effort assessed by respiratory muscles pressure-time product and by work of breathing (WOB). ⋯ In patients receiving NIV for moderate to severe acute hypercapnic respiratory failure, the use of HME lessens the efficacy of NIV in reducing effort compared to HH.