Intensive care medicine
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Intensive care medicine · Feb 2002
Randomized Controlled Trial Clinical TrialPhysiological effects of constant versus decelerating inflation flow in patients with chronic obstructive pulmonary disease under controlled mechanical ventilation.
To study the cardiorespiratory effects of inspiratory flow rate and waveform in COPD patients. ⋯ Changing the ventilator in volume-controlled mode with a DF or CF profile has no significant cardiorespiratory effect in intubated COPD patients mechanically ventilated for acute respiratory failure.
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Intensive care medicine · Feb 2002
Randomized Controlled Trial Comparative Study Clinical TrialImpact of sepsis, lung injury, and the role of lipid infusion on circulating prostacyclin and thromboxane A(2).
To investigate whether plasma levels of prostacyclin (PGI2) and thromboxane A(2) (TxA2) are a function of the infusion rate of soybean-based fat emulsions, severity of systemic inflammation, and pulmonary organ failure. ⋯ The quantity of prostanoids formed and their subsequent utilization are dependent on the availability of precursor linoleic acid and are probably affected by the severity of SIRS or sepsis and the existence of pulmonary organ failure, respectively. Because TxA2 might be extracted by the injured lung, rapid infusion of soybean-based fat emulsions should be avoided in patients suffering from severe pulmonary organ failure.