Intensive care medicine
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Intensive care medicine · Feb 2004
Randomized Controlled Trial Clinical TrialEffects on skeletal muscle of intravenous glutamine supplementation to ICU patients.
To evaluate the effect of four doses of intravenous glutamine supplementation on skeletal muscle metabolism. ⋯ Intravenous glutamine supplementation to ICU patients for a period of five days resulted in normalization of plasma glutamine concentrations in a dose-dependent way whereas muscle glutamine concentrations were unaffected.
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Intensive care medicine · Feb 2004
Clinical TrialPatient State Index (PSI) measures depth of sedation in intensive care patients.
To investigate whether the electroencephalogram (EEG)-based Patient State Index (PSI) indicates the level of sedation as measured by Ramsay score in intubated and mechanically ventilated patients in the ICU. ⋯ As the high prediction probability and the analysis of paired comparisons suggest, PSI may be used to quantify the level of propofol/sufentanil sedation in ICU patients. Further studies are required to test whether these promising results can be verified for other drug combinations.
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Intensive care medicine · Feb 2004
Comparative StudyValidation of the new Intensive Care Nursing Scoring System (ICNSS).
To validate a new Intensive Care Nursing Scoring System (ICNSS). ⋯ Nursing workload varied between the different admission types. ICNSS explained a similar percentage of the variation of the admission scores of APACHE II and SAPSS II as TISS and discriminated between non-survivors and survivors. ICNSS is a suitable nursing workload instrument to be used with the TISS score.
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Intensive care medicine · Feb 2004
Comparative StudyChanges in FiO2 affect PaO2 with minor alterations in cerebral concentration of oxygenated hemoglobin during liquid ventilation in healthy piglets.
To measure the impact of changes in the fraction of inspired oxygen (FiO2) on systemic and cerebral oxygen supply in gas and liquid ventilated healthy animals. ⋯ Arterial blood gases were obtained 15 min after changing FiO2 and concentrations of cerebral oxygenated and total hemoglobin were determined with near infrared spectroscopy. During CMV an increase in FiO2 1.0 was associated with a constant rise in PaO2 but only a small increase in the cerebral concentration of oxygenated Hb. Initiation of PLV (at FiO2 of 1.0) caused a rapid drop in PaO2 towards values that were similar to CMV at FiO2 of 0.5. At FiO2 of 0.5 a reduction in oxygenated Hb was found in the 30 ml/kg filling group. Complete filling of the lungs with PFC caused a significant drop in total cerebral Hb concentration. CONCLUSIONS. According to our data, PLV in healthy lungs should be performed with a FiO2 of 1.0 and a small filling volume to avoid deterioration in cerebral oxygen supply.
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Intensive care medicine · Feb 2004
Comparative StudyPrediction of mortality in an Indian intensive care unit. Comparison between APACHE II and artificial neural networks.
To compare hospital outcome prediction using an artificial neural network model, built on an Indian data set, with the APACHE II (Acute Physiology and Chronic Health Evaluation II) logistic regression model. ⋯ Artificial neural networks, trained on Indian patient data, used fewer variables and yet outperformed the APACHE II system in predicting hospital outcome.