Intensive care medicine
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Intensive care medicine · Feb 2015
Review Meta AnalysisEffects of levosimendan for low cardiac output syndrome in critically ill patients: systematic review with meta-analysis and trial sequential analysis.
To assess the benefits and harms of levosimendan for low cardiac output syndrome in critically ill patients. ⋯ The available evidence is inconclusive whether or not levosimendan may have a beneficial effect on mortality due to risks of systematic errors and random errors. Further well-designed randomised trials are needed.
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Intensive care medicine · Feb 2015
Multicenter Study Observational StudyThe Iatroref study: medical errors are associated with symptoms of depression in ICU staff but not burnout or safety culture.
Staff behaviours to optimise patient safety may be influenced by burnout, depression and strength of the safety culture. We evaluated whether burnout, symptoms of depression and safety culture affected the frequency of medical errors and adverse events (selected using Delphi techniques) in ICUs. ⋯ The frequency of selected medical errors in ICUs was high and was increased when staff members had symptoms of depression.
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Intensive care medicine · Feb 2015
Multicenter Study Observational StudyVolume expansion in the first 4 days of shock: a prospective multicentre study in 19 French intensive care units.
To describe the current practices of volume expansion in French intensive care units (ICU). ⋯ High between-centre variability characterised all the aspects of FB prescription and monitoring, but overall haemodynamic exploration to help guide and monitor FB was infrequent.
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Intensive care medicine · Feb 2015
Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells.
Endothelial cell activation and dysfunction are involved in the pathophysiology of ARDS. Circulating endothelial cells (CECs) may be a useful marker of endothelial dysfunction and damage but have been poorly studied in ARDS. We hypothesized that the CEC count may be elevated in patients with sepsis-related ARDS compared to those with sepsis without ARDS. ⋯ The day-1 CEC count was significantly higher in ARDS patients than in other critically ill patients, and in moderate or severe ARDS patients compared to those with milder disease, making it a potentially useful marker of ARDS severity.