Intensive care medicine
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Intensive care medicine · Jun 2015
Observational StudyOutcomes associated with routine systemic antifungal therapy in critically ill patients with Candida colonization.
To assess the evolution of patient deep colonization by Candida spp. in a surgical ICU over an 8-year period. ⋯ Preemptive strategy of antifungal drug prescriptions in highly colonized ICU patients induced an increase in C. glabrata colonization without significant shift of colonization to other Candida spp. in surgical ICU patients. However, the potential detrimental impact of fluconazole on Candida ecology in ICU and/or on Candida susceptibility to antifungal drugs should be considered, and deserves further studies.