Intensive care medicine
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Intensive care medicine · Jul 2015
Randomized Controlled TrialIntravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial.
Acute kidney injury (AKI) is characterized by severe loss of glomerular filtration rate (GFR) and is associated with a prolonged intensive care unit (ICU) stay and increased risk of death. No interventions have yet been shown to prevent AKI or preserve GFR in critically ill patients. Evidence from mammalian physiology and small clinical trials suggests higher amino acid intake may protect the kidney from ischemic insults and thus may preserve GFR during critical illness. ⋯ Treatment with a daily IV supplement of standard amino acids did not alter our primary outcome, duration of renal dysfunction.