Intensive care medicine
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Intensive care medicine · Aug 2018
Randomized Controlled TrialConservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial.
Oxygen saturation monitoring for children receiving respiratory support is standard worldwide. No randomised clinical trials have compared peripheral oxygen saturation (SpO2) targets for critically ill children. The harm of interventions to raise SpO2 to > 94% may exceed their benefits. ⋯ A definitive clinical trial of peripheral oxygen saturation targets is feasible in critically ill children.
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Intensive care medicine · Aug 2018
Pathogen colonization of the gastrointestinal microbiome at intensive care unit admission and risk for subsequent death or infection.
Loss of colonization resistance within the gastrointestinal microbiome facilitates the expansion of pathogens and has been associated with death and infection in select populations. We tested whether gut microbiome features at the time of intensive care unit (ICU) admission predict death or infection. ⋯ Enterococcus status at ICU admission was associated with risk for death or all-cause infection, and rectal carriage of common ICU pathogens predicted specific infections. The gastrointestinal microbiome may have a role in risk stratification and early diagnosis of ICU infections.