Clinical therapeutics
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Clinical therapeutics · Jan 1985
Clinical Trial Controlled Clinical TrialDouble-blind study of benzydamine hydrochloride, a new treatment for sore throat.
Forty-four patients with sore throat participated in a placebo-controlled, double-blind clinical trial of benzydamine hydrochloride administered as a gargle. After medical evaluation and throat culture, 21 patients were treated with a solution containing benzydamine and 23 patients with a placebo solution. ⋯ Side effects were minimal and of no clinical significance. The findings indicate that benzydamine hydrochloride is safe and effective therapy for the signs and symptoms of sore throat.
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Clinical therapeutics · Jan 1985
Comparative Study Clinical Trial Controlled Clinical TrialA double-blind comparison of the new ibuprofen-codeine phosphate combination, zomepirac, and placebo in the relief of postepisiotomy pain.
In a double-blind, single-dose study, the analgesic effect of a combined ibuprofen-codeine phosphate preparation was compared with those of zomepirac and placebo in 127 patients with moderate or severe postepisiotomy pain. Both the combination and zomepirac were significantly more effective than placebo for up to six hours, but the onset of action of the combination was more rapid than that of zomepirac. The study was notable for the virtual absence of side effects.