Clinical therapeutics
-
Clinical therapeutics · Aug 2000
Randomized Controlled Trial Comparative Study Clinical TrialComparison of naratriptan and sumatriptan in recurrence-prone migraine patients. Naratriptan International Recurrence Study Group.
This randomized, double-blind, crossover study was undertaken to compare the incidence of headache recurrence after treatment with naratriptan or sumatriptan in migraine patients with a history of frequent headache recurrence (recurrence in > or =50% of successfully treated attacks). ⋯ These data suggest that naratriptan is a long-acting and well-tolerated addition to currently available medications for the treatment of acute migraine.
-
Clinical therapeutics · Aug 2000
Randomized Controlled Trial Clinical TrialDose-response effect of combination hydrocodone with ibuprofen in patients with moderate to severe postoperative pain.
The objective of this study was to demonstrate a dose-response effect with 1- and 2-tablet doses of combination hydrocodone 7.5 mg with ibuprofen 200 mg and placebo in patients with moderate to severe postoperative abdominal or gynecologic pain. ⋯ This study demonstrated that a 2-tablet dose of hydrocodone with ibuprofen provided significantly more analgesia than a 1-tablet dose (a positive dose-response effect) and that both doses were superior to placebo.