Clinical therapeutics
-
Clinical therapeutics · Jan 1986
Topical corticosteroid therapy for children: alclometasone dipropionate cream 0.05%.
The safety and efficacy of twice-daily applications of alclometasone dipropionate cream 0.05% were evaluated in 39 children with eczema during a three-week open study. Early-morning plasma cortisol levels were monitored at weekly intervals (visits 1, 2, and 3) for six children. ⋯ Plasma cortisol levels remained within the acceptable normal range of 7 to 25 micrograms/100 ml throughout the study in all 39 children. At the conclusion of treatment, a favorable global response--complete clearing of monitored signs and symptoms--was observed in 28 (72%) children, and marked or moderate improvement was recorded for seven (18%) children.
-
Clinical therapeutics · Jan 1985
Clinical Trial Controlled Clinical TrialDouble-blind study of benzydamine hydrochloride, a new treatment for sore throat.
Forty-four patients with sore throat participated in a placebo-controlled, double-blind clinical trial of benzydamine hydrochloride administered as a gargle. After medical evaluation and throat culture, 21 patients were treated with a solution containing benzydamine and 23 patients with a placebo solution. ⋯ Side effects were minimal and of no clinical significance. The findings indicate that benzydamine hydrochloride is safe and effective therapy for the signs and symptoms of sore throat.
-
Clinical therapeutics · Jan 1985
Comparative Study Clinical Trial Controlled Clinical TrialA double-blind comparison of the new ibuprofen-codeine phosphate combination, zomepirac, and placebo in the relief of postepisiotomy pain.
In a double-blind, single-dose study, the analgesic effect of a combined ibuprofen-codeine phosphate preparation was compared with those of zomepirac and placebo in 127 patients with moderate or severe postepisiotomy pain. Both the combination and zomepirac were significantly more effective than placebo for up to six hours, but the onset of action of the combination was more rapid than that of zomepirac. The study was notable for the virtual absence of side effects.
-
Clinical therapeutics · Jan 1984
Aprotinin in open-heart surgery of infants and children using the heart-lung machine.
The purpose of this study was to evaluate a new approach to managing thrombohemorrhagic diathesis in infants and children undergoing extracorporeal circulation during open-heart surgery. Treatment consisted of administering vitamin K1 and aprotinin preoperatively as well as during bypass and after neutralization of heparin. Operative techniques were either surface-induced deep hypothermia and total circulating arrest or conventional bypass with mild-to-moderate hypothermia. ⋯ Most of the infants, especially those with congenital cyanotic heart disease, had marked fibrinolysis and vitamin K1 deficiency preoperatively. All patients postoperatively exhibited fibrinolysis and proteolysis greatly exceeding normal values with increased bleeding tendency. The treatment significantly reduced blood loss and transfusion requirements.
-
Clinical therapeutics · Jan 1983
Clinical TrialA premarketing multicenter trial of lorazepam injection.
Before the introduction of lorazepam injection to the Canadian market, its usefulness and acceptability were assessed in an open multicenter study. Anesthesiologists in teaching hospitals across the country were asked to substitute lorazepam injection for their usual anxiolytic premedicant in ten patients and to complete a brief case report on each patient. ⋯ The adverse effect most often reported, accounting for 84% of the drug-related adverse reactions, was postoperative drowsiness, which highlighted the need to administer the drug at least two hours before surgery. The anesthesiologists found lorazepam injection to be a satisfactory premedicant, rating it excellent to good in 73% of the patients treated.