Revista de neurologia
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Revista de neurologia · Nov 2008
Case Reports[Bullous pemphigoid and amyotrophic lateral sclerosis].
Bullous pemphigoid is the most frequent blistering disease and has been found associated to several neurological diseases, including amyotrophic lateral sclerosis. ⋯ The association does not seem to occur by chance and we suggest an autoimmune pathogenetic mechanism consisting in a crossed reaction between bullous pemphigoid antigen 1 and the protein dystonin, which is involved in the organisation/integrity of the neuronal cytoskeleton.
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Revista de neurologia · Nov 2008
[Metoclopramide as a painkiller for intense migraine headache in emergency departments].
Migraine headache is an uncommon but disabling clinical entity when patients go to an urgency room with a severe migraine attack and digestive symptoms. Intravenous non-steroidal anti-inflammatory drugs, paracetamol and triptans represent the first line drugs in the migraine therapy in emergency departments elsewhere however the low efficacy and the limitations of the oral way for vomiting determine a difficult situations in some migraine patients. Metoclopramide is an anti-emetic drug which indication in migraine for vomiting and as an adjunctive drug to other analgesic has been reported elsewhere but the analgesic features of this drug in monotherapy has not been largely study in the medical literature. ⋯ The patients showed a important improvement after 10 mg of intravenous metoclopramide exclusively with no other analgesic drug.