Alcoholism, clinical and experimental research
-
Alcohol. Clin. Exp. Res. · Aug 2010
Randomized Controlled Trial Comparative StudyAnalgesic effects of ethanol are influenced by family history of alcoholism and neuroticism.
Although personality factors and family history of substance abuse influence how individuals experience pain and respond to analgesics, the combined effects of those factors have not been extensively studied. The objective of this study was to consider the possible role of personality trait of neuroticism and family history of alcoholism on the experience of pain and their role in the analgesic response to an ethanol challenge. ⋯ These findings support the conclusion that neuroticism and family history of alcoholism both influence the analgesic response of alcohol. Individuals with high N scores and FHP have the strongest response to ethanol analgesia particularly on the low exposure to alcohol.