Annals of neurology
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Annals of neurology · Sep 2011
Review Meta AnalysisComputed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds.
Cerebral perfusion imaging with computed tomography (CT) or magnetic resonance (MR) is widely available. The optimum perfusion values to identify tissue at risk of infarction in acute stroke are unclear. We systematically reviewed CT and MR perfusion imaging in acute ischemic stroke. ⋯ CT and MR perfusion imaging viability thresholds in stroke are derived from small numbers of patients, variable perfusion analysis methods and definitions of tissue states. Greater consistency of methods would help determine reliable perfusion viability values for wider clinical use of perfusion imaging.
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Annals of neurology · Sep 2011
Randomized Controlled TrialA randomized, pilot trial of etanercept in dermatomyositis.
The aims of this pilot study were to assess (1) the safety and tolerability of etanercept in dermatomyositis (DM); (2) the feasibility and safety of a forced prednisone taper; and (3) outcome measures, including those recommended by the International Myositis Assessment Clinical Study (IMACS) group. ⋯ The findings of no major safety concerns and a steroid-sparing effect in our study suggest that further investigation of etanercept as a treatment for DM is warranted.
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Annals of neurology · Sep 2011
Biography Historical ArticleRichard Olney's perspective as physician-scientist and patient.