Annals of neurology
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Annals of neurology · Aug 2012
Randomized Controlled TrialA randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.
Based on findings in animal models of autoimmune optic nerve inflammation, we have assessed the safety and efficacy of erythropoietin in patients presenting with a first episode of optic neuritis. ⋯ These results give the first indications that erythropoietin might be neuroprotective in optic neuritis.
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Annals of neurology · Aug 2012
Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis.
We sought to determine whether vitamin D status is associated with developing new T2 lesions or contrast-enhancing lesions on brain magnetic resonance imaging (MRI) in relapsing multiple sclerosis (MS). ⋯ Vitamin D levels are inversely associated with MS activity on brain MRI. These results provide further support for a randomized trial of vitamin D supplementation.
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Annals of neurology · Aug 2012
Evidence that nuclear factor IA inhibits repair after white matter injury.
Chronic demyelination can result in axonopathy and is associated with human neurological conditions such as multiple sclerosis (MS) in adults and cerebral palsy in infants. In these disorders, myelin regeneration is inhibited by impaired differentiation of oligodendrocyte progenitors into myelin-producing oligodendrocytes. However, regulatory factors relevant in human myelin disorders and in myelin regeneration remain poorly understood. Here we have investigated the role of the transcription factor nuclear factor IA (NFIA) in oligodendrocyte progenitor differentiation during developmental and regenerative myelination. ⋯ These studies suggest that NFIA participates in the control of oligodendrocyte progenitor differentiation and may contribute to the inhibition of remyelination in human myelin disorders.