Annals of neurology
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Annals of neurology · Aug 2014
Functional anatomy of subthalamic nucleus stimulation in Parkinson disease.
We developed a novel method to map behavioral effects of deep brain stimulation (DBS) across a 3-dimensional brain region and to assign statistical significance after stringent type I error correction. This method was applied to behavioral changes in Parkinson disease (PD) induced by subthalamic nucleus (STN) DBS to determine whether these responses depended on anatomical location of DBS. ⋯ Our method identified DBS-induced behavioral changes that depended significantly on DBS site. These results do not support complete functional segregation within STN, because movement improved with DBS throughout, and mood improved with dorsal STN DBS. Rather, findings support functional convergence of motor, cognitive, and limbic information in STN.
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Annals of neurology · Aug 2014
A peek behind the curtain: peer review and editorial decision making at Stroke.
A better understanding of the manuscript peer-review process could improve the likelihood that research of the highest quality is funded and published. To this end, we aimed to assess consistency across reviewers' recommendations, agreement between reviewers' recommendations and editors' final decisions, and reviewer- and editor-level factors influencing editorial decisions at the journal Stroke. ⋯ This analysis of the peer-review process at Stroke identified several factors that might be targeted to improve the consistency and fairness of the overall process.