Annals of neurology
-
Annals of neurology · Oct 2012
Relation of neuropathology to cognition in persons without cognitive impairment.
A study was undertaken to examine the relation of Alzheimer disease (AD) pathology, cerebral infarcts, and Lewy body (LB) pathology to cognition in persons without cognitive impairment. ⋯ AD pathology and macroscopic infarctions are common in older persons without cognitive impairment and are related to episodic and working memory.
-
Annals of neurology · Oct 2012
Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain.
Previously we reported that exposure of 6-day-old (P6) rhesus macaques to isoflurane for 5 hours triggers a robust neuroapoptosis response in developing brain. We have also observed (unpublished data) that isoflurane causes apoptosis of cellular profiles in the white matter that resemble glia. We analyzed the cellular identity of the apoptotic white matter profiles and determined the magnitude of this cell death response to isoflurane. ⋯ Exposure of the infant rhesus macaque brain to isoflurane for 5 hours is sufficient to cause widespread apoptosis of neurons and OLs throughout the developing brain. Deletion of OLs at a stage when they are just beginning to myelinate axons could potentially have adverse long-term neurobehavioral consequences that might be additive to the potential consequences of isoflurane-induced neuroapoptosis.
-
Annals of neurology · Oct 2012
Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura.
Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options. ⋯ The observations here identify an entirely novel treatment strategy for migraine.