Auris, nasus, larynx
-
Auris, nasus, larynx · Dec 2016
Randomized Controlled TrialRandomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer.
Radiation-induced mucositis (RIM) in chemoradiotherapy (CRT) for head and neck cancer (HNC) causes severe pain and worsens CRT compliance, QOL and outcome. Following retrospective reports, we conducted a randomized trial of the safety and efficacy of gabapentin for RIM-associated pain during CRT. ⋯ This pilot study is the first prospective randomized trial of gabapentin for RIM-related pain. Gabapentin had no apparent beneficial effect. Further research into agents for RIM-related pain is warranted.