Pathologie-biologie
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Pathologie-biologie · Mar 1994
Review[Bias of index of T-lymphocytes and chronic inflammatory dermatoses].
The pathogenesis of chronic inflammatory and autoimmune diseases is still not understood. The hypothesis that a bias in the T cell receptor repertoire could explain the susceptibility of some individuals to a particular disease was recently proposed on the basis of results obtained in animal models of human diseases. In this review, we focus on the structure of the T cell receptor and on the new insights in the study of the T cell repertoire in human inflammatory diseases, with special emphasis to skin disorders.
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Pathologie-biologie · Mar 1994
ReviewThe rationale for xenotransplantation as a solution to the donor organ shortage.
This paper describes the current level of activity in organ transplantation and illustrates that human organ donors are never going to be sufficiently numerous to fill the clinical needs of potential organ recipients. Xenografts are proposed as an alternative solution and arguments are presented to suggest that xenografts from primates to man will not be an appropriate organ source in most cases. Finally the possibility of genetically engineering a pig to provide organs for human use is proposed.