Early human development
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Early human development · Aug 2008
Review Practice GuidelineHow to tackle bleeding and thrombosis in the newborn.
Bleeding and its management represent common clinical problems in neonatal intensive care, particularly in pre-term infants. Frank and severe single organ haemorrhage (e.g. pulmonary or gastrointestinal in association with necrotising enterocolitis) is less common, but may require urgent resuscitation and clinical stabilisation. Intracranial bleeding is always potentially of greatest concern because of the neurological consequences, but the pathophysiological mechanism of the most characteristic form, intraventricular haemorrhage, remains incomplete. ⋯ The mainstay of treatment for bleeding in association with abnormalities of coagulation or thrombocytopenia remains blood products, although their role as prophylaxis to prevent bleeding in neonates without clinical signs of haemorrhage is less clear. The overwhelming majority of thromboembolic events in neonates occur in association with arterial or venous catheters, but the clinical features are very variable, including catheter dysfunction and local signs. The optimal treatment strategies including use of anticoagulants remain problematic in the absence of good clinical trials.
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Early human development · Aug 2008
Comparative StudySeason of birth and prevalence of overweight and obesity in Canada.
The contexts of prenatal life, such as one's season of birth, have been shown to influence health later in life. For example, research has shown a disproportionate number of schizophrenic patients are born during the late winter and early spring. The purpose of this study was to examine season of birth as a possible risk for overweight and obesity. ⋯ A greater proprtion of class III obese Canadians are born during the winter/spring, particularly in the 20-29 y age cohort. However, other factors (e.g. physical inactivity) represent greater risks for obesity than season of birth.