Early human development
-
Early human development · Nov 2012
Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis.
Very low birth weight neonates (≤ 1500 g, VLBWs) have a high rate of infection and distinct baseline immune function compared with more mature populations. In critically ill children and adults, sepsis increases subsequent infection risk. It is unknown whether sepsis modifies the risk of subsequent infection in VLBWs. ⋯ In contrast to findings in children and adults, EOS was not associated with an increased risk of LOS in this cohort. Age-specific investigations are needed to determine if post-sepsis immunologic alterations are present.
-
Early human development · Nov 2012
Maternal preeclampsia is associated with increased risk of necrotizing enterocolitis in preterm infants.
Necrotizing enterocolitis (NEC) is an important cause of mortality and morbidity in preterm infants. ⋯ Maternal preeclampsia may be an important risk factor for the development of NEC in premature infants as NEC incidence and severity of NEC were found to be significantly higher in premature infants born to preeclamptic mothers. The onset of NEC was significantly earlier and duration of NEC was longer in these infants.