Early human development
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Early human development · Jan 2012
Long-term neurological outcome of term-born children treated with two or more anti-epileptic drugs during the neonatal period.
Neonatal seizures may persist despite treatment with multiple anti-epileptic drugs (AEDs). ⋯ In term-born infants with seizures that required two or more AEDs outcome was poorer if seizure control failed. The number of AEDs required to reach seizure control and seizure aetiology had limited prognostic value.
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Early human development · Jan 2012
Skin conductance measurements as pain assessment in newborn infants born at 22-27 weeks gestational age at different postnatal age.
To assess pain or stress in newborn infants submitted to intensive care is important but difficult, as different observational pain scales are not always reliable in premature infants. As an indicator of pain, skin conductance (SC) measurements have detected increased sweating in newborn infants >28 gestational age (GA) submitted to heel lancing. ⋯ Changes in SC could be detected in infants at <28+0 PNA and related to the combination of heel lancing and squeezing. A maturational development of the SC was observed in infants born <28 GA. SC seems to be able to differentiate between pain and discomfort.
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Early human development · Nov 2011
Practice GuidelineEvidence based management guidelines for the detection and treatment of congenital CMV.
CMV is the most common congenital infection in newborns worldwide. Congenital CMV causes sensorineural hearing loss in a significant proportion of infected newborns, while the majority of newborns are asymptomatic. In the last three years there have been significant advances in the diagnosis and treatment of congenital CMV. We have developed practical evidence based guidelines for the management of congenital CMV.
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Early human development · Oct 2011
Health-related quality of life, emotional and behavioral problems in mild to moderate prematures at (pre-)school age.
There is a gap in the knowledge of longterm outcome of mild to moderate prematures compared to the extreme prematures or very low birth weight infants. ⋯ Children born at 32 to 36 weeks' gestational age do not experience an overall lower HR-QoL at 2 to 5 years of age. CPAP results in lower HRQoL scores for lung problems. The overall occurrence of behavioral and emotional problems does not differ from the general term-born pediatric population. Several subitems need further attention.