Herz
-
Comparative Study
[Protective effects of a delta-opioid-receptor agonist and an oxygen radical scavenger on postischemic hearts].
The cardioprotective effects of delta-opioid receptor agonists is mediated-at least in part-via oxygen radicals. Mannitol that is used in cardiac surgery because of its osmotic properties exerts its beneficial effects on stunned myocardium via scavenging hydroxyl radicals. The effects of a delta-opioid receptor agonist (D-Ala2-D-Leu5-Enkephalin [DADLE]), the radical scavenger mannitol and their combination on postischemic dysfunction in rabbit hearts were investigated. ⋯ Both substances improve the postischemic systolic and diastolic function and the relation between cardiac work and oxygen needed for this work. Thus, both substances offer promising properties in the clinic.