The Journal of clinical psychiatry
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Randomized Controlled Trial Multicenter Study
A double-blind, placebo-controlled study of the efficacy and safety of desvenlafaxine succinate in the treatment of major depressive disorder.
This study evaluated the efficacy and safety of desvenlafaxine succinate extended-release in major depressive disorder (MDD). ⋯ Desvenlafaxine is effective and well tolerated in the short-term treatment of MDD.
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Comparative Study
Decisional capacity to consent to research among patients with bipolar disorder: comparison with schizophrenia patients and healthy subjects.
Although clinical trials are needed to advance treatments for bipolar disorder, there has been little empirical research on the capacity of bipolar patients to consent to research. The aim of the present study was to evaluate levels of decisional capacity of bipolar patients compared with those of schizophrenia patients and healthy comparison subjects, as well as to examine whether symptom and neurocognitive deficits correlate with patients' decisional abilities. ⋯ The presence of bipolar disorder appears to be a risk factor for impaired understanding of information disclosed under standard consent procedures but should not be equated with a lack of competence to consent. The observed improvement in understanding with redisclosure of information suggests that enhanced consent procedures may be useful during enrollment of bipolar patients in research.