The Journal of clinical psychiatry
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Because patients with bipolar disorder spend more time experiencing depression than mania, bipolar disorder may be incorrectly diagnosed as unipolar depression. Patients presenting with depressive symptoms should be evaluated for present and lifetime mania symptomatology to ensure a correct diagnosis. Once a bipolar disorder diagnosis has been made, appropriate treatment choices, including mood stabilizers, antipsychotics, psychotherapy, and, in some cases, adjunctive antidepressants, can be made. After a patient has been stabilized, long-term treatment is necessary to prevent episode recurrence and to control subsyndromal symptoms.
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Comparative Study
An integrated analysis of olanzapine/fluoxetine combination in clinical trials of treatment-resistant depression.
To evaluate the efficacy of olanzapine/fluoxetine combination (OFC) versus olanzapine or fluoxetine monotherapy across all clinical trials of treatment-resistant depression sponsored by Eli Lilly and Company. ⋯ Results of this analysis showed that OFC-treated patients experienced significantly improved depressive symptoms compared with olanzapine- or fluoxetine-treated patients following failure of 2 or more antidepressants within the current depressive episode. Safety results for OFC were generally consistent with those for its component monotherapies. The total cholesterol increase associated with OFC was more pronounced than with olanzapine alone.
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Comment Letter Comparative Study
High-risk groups for charcoal-burning suicide attempt in Hong Kong, China, 2004.