Ophthalmology
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To examine risk factors for incident age-related macular degeneration (AMD) after combining data from 3 population-based cohort studies. ⋯ Pooled data support a growing body of evidence indicating that smoking is related to an increased risk of incident AMD. Current smokers were at higher risk of incident AMD than both past smokers and those who never smoked. The relationships found in this study between total serum cholesterol and incident geographic atrophy and neovascular AMD are not readily explained.