The International journal of artificial organs
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Randomized Controlled Trial Comparative Study Clinical Trial
The acid-base effects of continuous hemofiltration with lactate or bicarbonate buffered replacement fluids.
To evaluate, quantify and compare the effects of continuous veno-venous hemofiltration (CVVH) with lactate or bicarbonate-buffered replacement fluids on acid-base balance. ⋯ CVVH with lactate-buffered replacement fluids induces iatrogenic hyperlactatemia. Such hyperlactatemia is associated with an acidifying effect despite a positive buffer-base balance.