The International journal of artificial organs
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The objective of this work was to conduct pre-clinical feasibility studies to determine if a highly efficient, active-mixing, adult extracorporeal carbon dioxide removal (ECCO2R) system can safely be translated to the pediatric population. The Hemolung Respiratory Assist System (RAS) was tested in vitro and in vivo to evaluate its performance for pediatric veno-venous applications. ⋯ The Hemolung RAS was found to have gas exchange and pumping capabilities relevant to patients weighing 3-25 kg. Seven-day animal studies in juvenile sheep demonstrated that veno-venous extracorporeal support could be used safely and effectively with no significant adverse reactions related to device operation.
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Case Reports
Low-flow veno-venous extracorporeal CO2 removal: first clinical experience in lung transplant recipients.
Low-flow extracorporeal CO2 removal devices are easy to setup and manage and may provide valuable ventilation support. ⋯ Our data suggest that this new device is effective in removing CO2 and stabilizing the pH.