The American journal of medicine
-
Clinical Trial
Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer.
To determine the long-term impact of medical and surgical treatment of well differentiated papillary and follicular thyroid cancer. ⋯ Over the long term, for tumors > or = 1.5 cm that are not initially metastatic to distant sites, near-total thyroidectomy followed by 131I plus thyroid hormone therapy confers a distinct outcome advantage. This therapy reduces tumor recurrence and mortality sufficiently to offset the augmented risks incurred by delayed therapy, age > or = 40 at the time of diagnosis, and tumors that are much larger than 1.5 cm, multicentric, locally invasive, or regionally metastatic.