The American journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group.
To determine the pathogenesis and clinical course of lactic acidosis in adults receiving standard medical care. ⋯ In this first prospective study of the clinical course of acute lactic acidosis in adults, nearly all subjects had both hemodynamic and nonhemodynamic (metabolic) underlying causes, many of which independently predicted survival and most of which were refractory to standard care.