The American journal of medicine
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Clinical Trial Controlled Clinical Trial
Reduction of cortisol levels after single intra-articular and intramuscular steroid injection.
This study was undertaken to determine the influence of single intra-articular or intra muscular injections of methylprednisolone acetate on the hypothalamic-pituitary-adrenal axis. ⋯ The present study suggests that decreased adrenocortical secretion, as reflected in depressed cortisol levels, can result from a single, low-dose, intra-articular or intramuscular injection of depot corticosteroids.