The American journal of medicine
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Prospective studies have shown that bone mass, measured by any method and at any site, is inversely related to a woman's risk of fracture. Most types of fractures are more frequent in women with low bone mass. Bone mineral density measured in the proximal femur appears to have a stronger relationship to risk of hip fracture than bone density measured in other sites. ⋯ A woman's lifetime risk of hip fracture can be estimated from bone mass measurements made in the perimenopausal period. Although an individual's level of bone mass may vary from site to site, the incremental value of measuring bone mass in more than one site is not certain. Bone mass measurements, perhaps in combination with other risk factors for fracture, help define individuals with a high risk of fracture who stand to benefit most from efforts to prevent fractures.
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The aim of the study was to investigate the mechanisms of myocardial catecholamine refractoriness in septic shock. ⋯ An increase in the expression of Gi alpha could also be important in conditions other than chronic heart failure, eg, septic shock. An increase of Gi alpha could play a pathophysiologically relevant role in catecholamine refractoriness in septic shock and could provide a target for pharmacologic treatment in this condition.
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Randomized Controlled Trial Multicenter Study Clinical Trial
A randomized trial of hydroxychloroquine in early rheumatoid arthritis: the HERA Study.
Studies of the efficacy of hydroxychloroquine in rheumatoid arthritis have had methodological flaws and have failed to produce definitive results. The benefits and toxicity of hydroxychloroquine sulfate in 120 patients with rheumatoid arthritis of less than 2 years duration are assessed. ⋯ Over 36 weeks, hydroxychloroquine had a significant benefit on synovitis, pain, and physical disability of recent-onset rheumatoid arthritis, but did not benefit psychological function.
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The prolonged disability of patients suffering from chronic fatigue may be due to sustaining factors that are independent of the cause and subject to intervention. This study reexamined a cohort of patients with chronic fatigue to define medical and psychiatric predictors of persistent symptoms. ⋯ At initial examination, patients with chronic fatigue, more than eight medically unexplained physical symptoms (excluding symptoms in the case criteria for CFS), a lifetime history of dysthymic disorder, longer than 1.5 years of chronic fatigue, less than 16 years of formal education, and who were older than 38 years were the most likely to have persistence of symptoms of chronic fatigue at the 2.5-year follow-up.