The American journal of medicine
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Comment Comparative Study
Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly.
This study was performed to determine the effects of markers of inflammation (interleukin 6) and coagulation (D-dimer) on mortality and functional status in older persons. ⋯ Activation of the coagulation and inflammatory pathways is associated with mortality and decline in function, and may be part of the explanation for the development of a frailty phenotype in the elderly.
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Comment Clinical Trial Controlled Clinical Trial
Pharmacokinetic dosing of aminoglycosides: a controlled trial.
To evaluate whether individualized pharmacokinetic dosing of aminoglycosides can reduce nephrotoxicity and improve the outcome of patients with gram-negative sepsis. ⋯ These results suggest that individualized pharmacokinetic dosing of aminoglycosides reduces the incidence of nephrotoxicity and allows the use of greater doses of aminoglycosides.
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Comment
The relation of C-reactive protein levels to total and cardiovascular mortality in older U.S. women.
To determine whether serum C-reactive protein levels, a sensitive indicator of inflammation, are associated with the risk of cardiovascular mortality among older women. ⋯ C-reactive protein level was an independent predictor of cardiovascular mortality in older women.