The American journal of medicine
The most recent articles from:
Am. J. Med.
-
Characteristics of Vaccine Safety Observational Studies and Authors' Attitudes: A Systematic Review.
Post-licensure observational studies are the mainstay of vaccine safety evaluation. However, these studies have well-known methodological limitations, rendering them particularly vulnerable to unmeasured confounding. We sought to describe high-impact observational studies of vaccine safety, investigate the authors' attitudes towards their study's findings and limitations, and report on spin practices. ⋯ Although our findings are somewhat limited by subjectivity in study assessments, they suggest that editors and reviewers of high-impact journals should ensure the language used in reporting observational studies accurately reflects the findings and their limitations.