The American journal of medicine
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Am. J. Med.
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Observational Study
Frank´s Sign and cardiovascular risk: an observational descriptive study.
This study was undertaken to analyze the relationship between the diagonal earlobe crease and the main indices of cardiovascular risk, considering the crease's anatomical variations. ⋯ The diagonal earlobe crease is independently associated with higher cardiovascular risk scores, especially when the crease is complete, bilateral, deep, and has accessory creases.