Neurosurgery
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Clinical Trial
The impact of sedation on brain mapping: a prospective, interdisciplinary, clinical trial.
During awake craniotomies, patients may either be awake for the entire duration of the surgical intervention (awake-awake-awake craniotomy, AAA) or initially sedated (asleep-awake-asleep craniotomy, SAS). ⋯ Cognitive and motor performance were significantly influenced by prior sedation in the TIVA and RAS groups, but not in the AAA group. Therefore, prior sedation may be assumed to cause a change in the baselines, which may compromise brain mapping and thus endanger a patient's neurological outcome in the case of an SAS.
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Review Historical Article
The continuing evolution: biology and treatment of brain tumors.