Muscle & nerve
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Regenerative peripheral nerve interfaces (RPNIs) transduce neural signals to provide high-fidelity control of neuroprosthetic devices. Traditionally, rat RPNIs are constructed with ~150 mg of free skeletal muscle grafts. It is unknown whether larger free muscle grafts allow RPNIs to transduce greater signal. ⋯ Electrical signaling and tissue viability are optimal in smaller as opposed to larger RPNI constructs in a rat model.