Muscle & nerve
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Randomized Controlled Trial Comparative Study
Comparison of proximal and distal corticosteroid injections for carpal tunnel syndrome.
Evidence for the efficacy of distal corticosteroid injection compared with proximal injection in carpal tunnel syndrome (CTS) is inadequate. ⋯ Corticosteroid injections for CTS distal to the wrist are not inferior to proximal injections, yet they are more painful.
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Randomized Controlled Trial
Nerve hydrodissection for carpal tunnel syndrome: A prospective, randomized, double-blind, controlled trial.
In this study we explored the efficacy of nerve hydrodissection for mild-to-moderate carpal tunnel syndrome (CTS). ⋯ Our study demonstrates the therapeutic effects of nerve hydrodissection for mild-to-moderate CTS. Muscle Nerve 59:174-180, 2019.
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Randomized Controlled Trial Comparative Study
Comparison of nerve growth factor-induced sensitization pattern in lumbar and tibial muscle and fascia.
Nerve growth factor (NGF) induces profound hyperalgesia. In this study we explored patterns of NGF sensitization in muscle and fascia of distal and paraspinal sites. ⋯ Spatial mechanical sensitization differs between muscle and fascia. Thoracolumbar fasciae appear more sensitive than tibial fasciae and may be major contributors to low back pain, but the temporal sensitization profile is similar between paraspinal and distal sites. Muscle Nerve 52: 265-272, 2015.
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Randomized Controlled Trial
Pain and small fiber function in Charcot-Marie-Tooth disease type 1A.
Charcot-Marie-Tooth (CMT) disease type 1A is the most common form of CMT. The main clinical features are distal weakness, sensory loss, and skeletal deformities. Although pain is a frequent complaint, small fiber involvement in CMT1A has not been studied extensively. ⋯ Our findings confirm that CMT1A patients have significant pain, which is more likely to be multifactorial in origin and suggests that a proportion of patients have small fiber dysfunction affecting mainly thinly myelinated Aδ fibers.
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Randomized Controlled Trial
Influence of intrinsic noise generated by a thermotesting device on thermal sensory detection and thermal pain detection thresholds.
Various factors can influence thermal perception threshold measurements and contribute significantly to unwanted variability of the tests. To minimize this variability, testing should be performed under strictly controlled conditions. Identifying the factors that increase the variability and eliminating their influence should increase reliability and reproducibility. ⋯ Our results show that thermal sensory thresholds measured with the two devices are comparable. However, our data suggest that, for studies with repeated measurements on the same subjects, a silent thermotesting device may allow detection of smaller differences in the treatment effects and/or may permit the use of a smaller number of tested subjects. Muscle Nerve 40: 257-263, 2009.