Pacing and clinical electrophysiology : PACE
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Pacing Clin Electrophysiol · Sep 2016
Randomized Controlled TrialBiomarkers in Persistent AF and Heart Failure: Impact of Catheter Ablation Compared with Rate Control.
To investigate the effects of catheter ablation and rate control strategies on cardiac and inflammatory biomarkers in patients with heart failure and persistent atrial fibrillation (AF). ⋯ Catheter ablation, compared with rate control, in patients with heart failure and persistent AF was associated with significant reduction in MR-proANP, which correlated with physiological and symptomatic improvement. Ablation-based rhythm control may induce beneficial cardiac remodeling, unrelated to changes in inflammatory state. This may have prognostic implications, which require confirmation by event end point studies.