Clinical and investigative medicine. Médecine clinique et experimentale
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Genetic polymorphisms of the Interleukin-10 (IL-10) promoter have been implicated in several autoimmune diseases, including seronegative spondyloarthropathies. This study investigated whether single nucleotide polymorphisms (SNPs) and haplotypes of IL-10 are associated with ankylosing spondylitis (AS), a common subtype of spondyloarthritis (SpA). ⋯ Our results indicate that the gene haplotype of IL-10 can contribute to the susceptibility to AS in a Chinese population.
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The aim of this study is to histopathalogically compare the myotoxic effects of a single injection of levobupivacaine, bupivacaine and ropivacaine in rat skeletal muscle. ⋯ Levobupivacaine's myotoxic effect is qualitatively similar to that seen (and previously reported) with bupivacaine and ropivacaine. Levobupivacaine was found to be quantitatively less myotoxic than bupivacaine and ropivacaine after a single intramuscular injection, only two days after injection. Myonecrosis developed after a single intramuscular injection of local anesthetic but was completely regenerated by the 20th day after injection.
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Few systematic studies have focused on determinants of cumulative research funding (CRF), a measure of research productivity among career researchers world-wide. Using researchers funded by the Canadian Institutes for Health Research (CIHR), this exploratory study quantifies the association between CIHR-investigator roles and CRF obtained from the CIHR. ⋯ Demonstrated associations between investigator-level CRF and predictors suggest that CRF should be considered in the context of investigators' multiple roles. The study, without establishing causality, also documents evidence of multi-lateral returns to the enterprise of academic research from salary and trainee awards. The major limitation is that CRF and predictors are derived from a single funding agency. Findings should be viewed as preliminary and should serve to develop hypotheses for future, comprehensive research.