International journal of pharmaceutics
-
The natural gamma-cyclodextrin (gammaCD) is like linear water-soluble dextrins, and unlike the natural alpha- and beta-cyclodextrins (alphaCD and betaCD), digested by salivary and pancreatic amylase. This gives gammaCD a very favorable toxicological profile. However, its usage is hampered by its relatively low solubilizing effect and tendency to form turbid solutions. ⋯ For example, 80:20 mixture of gammaCD and HPgammaCD is up to 50% more effective solubilizer for dexamethasone and hydrocortisone than expected based on the solubilizing effects of the individual cyclodextrins. Mixing alphaCD or betaCD with their more water-soluble derivatives only resulted in additive effects. Mixing gammaCD with HPgammaCD resulted in synergistic effect.