International journal of pharmaceutics
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Pain accompanying intravenous injections of propofol is a major problem in anesthesia. Pain is ascribed to the interaction of propofol with the local vasculature and could be impacted by rapid dissolution of the emulsion formulation to release the drug. In this paper, we measure the dissolution of propofol emulsions including the commercial formulation Diprivan(®). ⋯ Drug release from emulsions occurs very rapidly after injection. This could be a contributing factor to pain on injection of propofol emulsions.