Annals of plastic surgery
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Annals of plastic surgery · Nov 1980
Comparative Study Clinical TrialTopical and systemic antimicrobial agents in burns.
Infection is the major cause of morbidity and mortality in burns. Burn wound infection is defined as burn wound bacterial proliferation in a density equal to or greater than 10(5) bacteria per gram of tissue. Gram-negative bacteria, notably Pseudomonas aeruginosa, as well as staphylococci and fungal opportunists, have been identified as prominent invaders. ⋯ Topical antimicrobial therapy is indicated in all hospitalized burn patients. Short-term use of systemic antimicrobials for prophylaxis and treatment is required in all moderate and major burns, specifically for early prophylaxis, perioperative prophylaxis, and clinical infection. Antimicrobial choice is based on specific patient or environmental bacteriological data.