International journal of rehabilitation research. Internationale Zeitschrift für Rehabilitationsforschung. Revue internationale de recherches de réadaptation
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Peripheral nerve pathology in patients with severely affected complex regional pain syndrome type I.
Complex regional pain syndrome type I (CRPS-I) is a chronic pain syndrome with no clinical evidence of nerve injury; however, recently, changes in muscle tissue have been found in case of CRPS-I. Our aim was to search for histological changes in peripheral nerves of amputated limbs from patients with therapy-resistant CRPS-I that could justify muscle tissue changes. Fifteen patients with CRPS-I (duration >1 year) were included. ⋯ The morphometric results of the other nerves are more difficult to interpret because of the absence of good-quality control data from the literature. However, the percentages of nerve fibers greater than 12 μm seem to lie within the normal range. Besides the known pathology of thin nerve fibers innervating the skin or blood vessels in CRPS-I, this study also shows pathological changes more proximal in the nerves, especially in the sural nerve.
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The aim of this study was to validate the Tampa Scale of Kinesiophobia for Parkinson's disease (TSK-PD). This was a cross-sectional evaluation of the psychometric properties of an adapted questionnaire. The psychometric testing included confirmatory factor analysis, reliability by internal consistency (Cronbach's α) and test-retest reliability (intraclass correlation coefficient), construct validity by comparing TSK-PD with the Falls Efficacy Scale-International (FES-I), the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS), the Hospital Anxiety and Depression Score (HADS) and the Short-Form Health Survey (SF-36) (Pearson's correlations), and sensitivity to change by calculating the smallest detectable change. ⋯ The smallest detectable change was 11. The TSK-PD had a good factorial structure and satisfactory psychometric properties. Its use is recommended for clinical and research purposes.