Diabetes care
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Randomized Controlled Trial
Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial.
To test the effects of two Mediterranean diet (MedDiet) interventions versus a low-fat diet on incidence of diabetes. ⋯ MedDiets without calorie restriction seem to be effective in the prevention of diabetes in subjects at high cardiovascular risk.
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We explored the possibility that perturbations in amniotic fluid glucose, insulin, and insulin-like growth factor-binding protein 1(IGFBP1) and/or metabolic acids exist before routine screening for GDM. ⋯ Fetuses are exposed to increased amniotic fluid glucose before 15 weeks of gestation, suggesting that metabolic perturbations are underway before diagnosis and that earlier screening and intervention may be warranted.