Cancer chemotherapy and pharmacology
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Cancer Chemother. Pharmacol. · Oct 2007
Comparative StudyLocal delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model.
Dose-limiting adverse effects of thrombocytopenia and leukopenia prevent augmentation of current temozolomide (TMZ) dosing protocols; therefore, we hypothesized that the direct intracranial delivery of TMZ would lead to improved efficacy in an animal model of malignant glioma in an animal model. ⋯ The survival of tumor-bearing animals was improved with local delivery of TMZ compared with systemic administration. XRT in combination with intracranial TMZ did not cause additional toxicity and prolonged the survival even further.