Cancer chemotherapy and pharmacology
-
Cancer Chemother. Pharmacol. · Mar 2009
ReviewPhase 0 clinical trials in oncology: a paradigm shift for early drug development?
To review the potential impact of Phase 0 trials conducted under the United States Food and Drug Administration (FDA) exploratory IND guidance on oncology drug development. ⋯ The potential of this novel pathway to accelerate drug development makes it worthy of further exploration, and National Cancer Institute has recently completed a Phase 0 trial demonstrating its applicability to targeted anticancer agents.