Cancer chemotherapy and pharmacology
-
Cancer Chemother. Pharmacol. · Aug 2015
Meta AnalysisPopulation pharmacokinetics of kahalalide F in advanced cancer patients.
In this study, we characterize the population pharmacokinetics of kahalalide F (KF), a novel marine anticancer drug, after intravenous (i.v.) administration in advanced cancer patients. ⋯ The integration of pharmacokinetic data from six clinical studies demonstrated KF linear elimination from plasma, dose-proportional exposure and time-independent pharmacokinetics. Based on analyzed data, no clinically relevant covariates were identified as predictors of KF pharmacokinetics.