Journal of endocrinological investigation
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J. Endocrinol. Invest. · Oct 2012
Comparative StudyAssociation of leptin receptor gene polymorphisms and essential hypertension in a Chinese population.
The leptin receptor (LEPR) is an important regulator of leptin activity and resistance. Several single nucleotide polymorphisms (SNP) of LEPR have been linked to diseases accompanying obesity and/or obesity-related diseases in different populations. However, the results from published studies remain inconsistent rather than conclusive. ⋯ LEPR polymorphisms may be a marker for susceptibility to essential hypertension in Chinese subjects, and be involved in the development of several features including dyslipidemia and impaired glucose regulation in hypertension subjects.